Nat Chem Biol. 2016 Apr 18 Light-induced nuclear export reveals rapid dynamics of epigenetic modifications. Yumerefendi H, Lerner AM, Zimmerman SP, Hahn K, Bear JE, Strahl BD, Kuhlman B. We engineered a photoactivatable system for rapidly and reversibly exporting proteins from … Continued

Science. 2016;352(6286):687-90 Design of structurally distinct proteins using strategies inspired by evolution. Jacobs TM, Williams B, Williams T, Xu X, Eletsky A, Federizon JF, Szyperski T, Kuhlman B.   Natural recombination combines pieces of preexisting proteins to create new tertiary structures and … Continued

  J Chem Theory Comput. 2015;11(2):609-622. A Combined Covalent-Electrostatic Model of Hydrogen Bonding Improves Structure Prediction with Rosetta. O’Meara MJ, Leaver-Fay A, Tyka M, Stein A, Houlihan K, DiMaio F, Bradley P, Kortemme T, Baker D, Snoeyink J, Kuhlman B. … Continued

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins Gurkan Guntas, Ryan A. Hallett, Seth P. Zimmerman, Tishan Williams, Hayretin Yumerefendi, James E. Bear, Brian Kuhlman Proc Natl Acad Sci U S A. 2015, … Continued

Nature Biotechnolgy. 2014 v32(2):191-8. Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Lewis SM, Wu X, Pustilnik A, Sereno A, Huang F, Rick HL, Guntas G, Leaver-Fay A, Smith EM, Ho C, Hansen-Estruch C, Chamberlain … Continued